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Advances in Biomedicine and Pharmacy

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Research Article

Chemical constituents of Salvia sclarea from Kashmir (India).

Masood-ur-Rahman 1, Iram Ayoob 2, Khursheed A. Bhat 3, Mohammad A. Khuroo 2, Tabassum Ara1, Shakeel-u-Rehman 1,3*

Abstract

Salvia sclarea (Lamiaceae) commonly known as clarysage, is a medicinally important herb showing broad range of biological activities. This plant is mainly known because of its pleasantly smelling essential oils rich in linalool and linalyl acetate. In addition to linalool and linalyl acetate (major essential oil secondary metabolites), the peculiar aromatic note of the essential oil is because of the minor constituents including a-terpineol, geranyl acetate, (E)-caryophyllene, limonene, thymol, nerol, geranyl acetate etc. Phytochemical investigation of the aerial parts of this plant yielded nine compounds i.e. ß-sitosterol, a-amyrin, ursolic acid, oleanolic acid, betulinic acid, sclareol, salvigenin, acacetin and norartocarpetin. The structures of these compounds have been established by spectroscopic methods (UV, IR, 1H NMR, 13C NMR and MS) in light of literature. Structure of ursolic acid has also been established by HMBC experiments. Ursolic acid, oleanolic acid, betulinic acid, salvigenin, acacetin and norartocarpetin are reported for the first time from this plant.
Keywords: Salvia sclarea, triterpenes, flavones, sclareol, salvigenin, NMR.